abstract：:Pemphigus is an autoimmune intraepidermal bullous disease involving the skin and mucous membranes. There are four clinically recognized variants of this disease. The histopathologic hallmark is acantholysis, which is disruption of normal cell-to-cell adhesion. Patients produce an IgG antibody directed against an antig...

journal_title：Annals of internal medicine

authors：

更新日期：1980-03-01 00:00:00

abstract：:The clinical significance of anatomic substage was assessed in 130 patients with Hodgkin's disease in pathologic stage III-A: stage III1-A includes involvement of spleen, or splenic, celiac, or portal nodes, or any combination of these; stage III2-A includes involvement of para-aortic, iliac, or mesenteric nodes, with...

journal_title：Annals of internal medicine

authors： Stein RS,Golomb HM,Diggs CH,Mauch P,Hellman S,Wiernik PH,Ultmann JE,Rosenthal DS

更新日期：1980-02-01 00:00:00

abstract：:This paper outlines the clinical, serologic, and immunogenetic differences and similarities of Sjögren's syndrome alone (primary) and Sjögren's syndrome associated with rheumatoid arthritis and systemic lupus erythematosus (secondary). The immunoregulation in Sjögren's syndrome is discussed and the incidence of immune...

journal_title：Annals of internal medicine

authors： Moutsopoulos HM,Chused TM,Mann DL,Klippel JH,Fauci AS,Frank MM,Lawley TJ,Hamburger MI

更新日期：1980-02-01 00:00:00

abstract：:Disturbances of urinary bladder function are well-recognized problems in diabetic patients and are generally attributed to peripheral neuropathy. Because of the difficulties inherent in the histologic examination of the peripheral autonomic nerves, little is known about the pathology of these nerves. Recently, alterat...

journal_title：Annals of internal medicine

authors： Mastri AR

更新日期：1980-02-01 00:00:00

abstract：:We examined the survival time and costs of therapy for patients with end-stage renal disease. A computer simulation model of the current system was constructed to estimate the cost-effectiveness of home and center hemodialysis and live related as well as cadaver donor renal transplantation. Analysis of the simulation ...

journal_title：Annals of internal medicine

authors： Roberts SD,Maxwell DR,Gross TL

更新日期：1980-02-01 00:00:00

abstract：:Adverse effects to D-penicillamine were studied prospectively over 3 years in 259 patients with rheumatoid arthritis. Ninety-five percent had had gold therapy previously, yet 70% benefited from D-penicillamine therapy. Of the 275 courses given, 160 (58%) were complicated by at least one reaction, including rashes (44%...

journal_title：Annals of internal medicine

authors： Stein HB,Patterson AC,Offer RC,Atkins CJ,Teufel A,Robinson HS

更新日期：1980-01-01 00:00:00

abstract：:A case of a patient with metastatic cancer raises the issues of patient refusal of treatment, euthanasia, and unintended side effects of therapy. For each management dilemma, there are relevant ethical and legal considerations, justifications, and conclusions. In addition, psychological and social influences on the de...

journal_title：Annals of internal medicine

authors： Lo B,Jonsen AR

更新日期：1980-01-01 00:00:00

abstract：:For years patients hospitalized with viral hepatitis have been placed in two categories of isolation--enteric precautions and blood precautions. This strategy was based on the inability to differentiate between hepatitis A and B and on the assumption that feces and blood from patients with either type might be infecti...

journal_title：Annals of internal medicine

authors： Favero MS,Maynard JE,Leger RT,Graham DR,Dixon RE

更新日期：1979-12-01 00:00:00

abstract：:In five patients with hypertension and marked impairment of renal function due to renal artery stenosis in a solitary functioning kidney, a nonsurgical technique, percutaneous transluminal angioplasty, was used to dilate the stenotic renal artery. Blood pressure improved in all five patients, and renal function improv...

journal_title：Annals of internal medicine

authors： Weinberger MH,Yune HY,Grim CE,Luft FC,Klatte EC,Donohue JP

更新日期：1979-11-01 00:00:00

abstract：:Two hundred forty previously healthy military personnel with nonstreptococcal upper respiratory infections were prospectively studied to define the incidence and clinicopathologic characteristics of possible virus-associated glomerulonephritis. Nine patients without preceding streptococcal infection had erythrocyte ca...

journal_title：Annals of internal medicine

authors： Smith MC,Cooke JH,Zimmerman DM,Bird JJ,Feaster BL,Morrison RE,Reimann BE

更新日期：1979-11-01 00:00:00

abstract：:Arteriohepatic dysplasia (Alagille's syndrome) is presumed to be one of the familial intrahepatic cholestatic syndromes, all of which present with neonatal jaundice or failure to thrive, or both. We report the findings in five patients with this syndrome, four of whom have been followed into adulthood. In addition to ...

journal_title：Annals of internal medicine

authors： Riely CA,Cotlier E,Jensen PS,Klatskin G

更新日期：1979-10-01 00:00:00

abstract：:Molecular analysis of normal and abnormal human globin genes and their gene products has recently provided information on the precise genetic events that result in hemoglobinopathies. In the case of structurally abnormal hemoglobins, the following mechanisms can be invoked: single nucleotide base substitutions leading...

journal_title：Annals of internal medicine

authors： Forget BG

更新日期：1979-10-01 00:00:00

abstract：:Coronary artery spasm is an important pathogenetic mechanism in some forms of myocardial ischemic disease. Factors that may be important in the genesis of spasm include the autonomic nervous system, prostaglandins, endoperoxides, thromboxanes, and the calcium availability to the contractile apparatus. Spasm results in...

journal_title：Annals of internal medicine

authors： Luchi RJ,Chahine RA,Raizner AE

更新日期：1979-09-01 00:00:00

abstract：:Recently developed radioligand binding techniques permit direct investigation of the alpha- and beta-adrenergic receptors for catecholamines in a wide variety of tissues. These techniques allow the receptors to be quantitated, characterized, and studied under varying conditions of physiologic and pathophysiologic inte...

journal_title：Annals of internal medicine

authors： Lefkowitz RJ

更新日期：1979-09-01 00:00:00

abstract：:In two patients with thyroiditis caused by Coccidioides immitis, presented thyroid symptoms and findings were characteristic of subacute thyroiditis. Fine needle aspiration biopsy of the thyroid proved useful in establishing the diagnosis of coccidioidomycosis. This is the first report of coccidioidomycosis presenting...

journal_title：Annals of internal medicine

authors： Loeb JM,Livermore BM,Wofsy D

更新日期：1979-09-01 00:00:00

abstract：:Questionnaire II of the National Study of Internal Medicine Manpower was directed to all of the 1502 subspecialty training programs in the United States and Puerto Rico. The overall response rate was 86%. For the years 1972-1973 through 1976-1977 the number of fellows in subspecialty training grew at an average rate o...

journal_title：Annals of internal medicine

authors： Tarlov AR,Weil PA,Schleiter MK

更新日期：1979-08-01 00:00:00

abstract：:Poststreptococcal acute glomerulonephritis is prototypic of the immunologic glomerulonephritides. It most commonly follows streptococcal infection of the pharynx or skin. The diagnosis is usually not difficult when a nephritic clinical presentation (with such manifestations as hematuria, edema, and hypertension) is as...

journal_title：Annals of internal medicine

authors： Nissenson AR,Baraff LJ,Fine RN,Knutson DW

更新日期：1979-07-01 00:00:00

abstract：:We performed immunohistopathologic studies on biopsied lung tissue obtained from two patients with lupus pneumonitis using immunofluorescence, immunoperoxidase, electron microscopy, and acid-microelution. In both patients, immunofluorescence showed granular deposits of IgG, the third component of complement (C3), and ...

journal_title：Annals of internal medicine

authors： Inoue T,Kanayama Y,Ohe A,Kato N,Horiguchi T,Ishii M,Shiota K

更新日期：1979-07-01 00:00:00

abstract：:Within 4 days, two oncology patients in the Clinical Research Unit had bacteremia causes by group Y Neisseria meningitidis. Three additional patients, identified by prevalence survey, were found to have nasopharyngeal colonization with that serogroup, compared with only one employee (not associated with patients) and ...

journal_title：Annals of internal medicine

authors： Cohen MS,Steere AC,Baltimore R,von Graevenitz A,Pantelick E,Camp B,Root RK

更新日期：1979-07-01 00:00:00

abstract：:Three patients with advanced Graves' ophthalmopathy were treated with cyclophosphamide. All had proptosis and diplopia. One patient had disabling iatrogenic Cushing's syndrome from steroid treatment of the ophthalmopathy and had undergone bilateral orbital decompression before cyclophosphamide therapy; steroids could ...

journal_title：Annals of internal medicine

authors： Bigos ST,Nisula BC,Daniels GH,Eastman RC,Johnston HH,Kohler PO

更新日期：1979-06-01 00:00:00

abstract：:The frequency of solid tumors was evaluated in 628 consecutive patients with multiple myeloma who had been treated with various melphalan-prednisone combinations. Among those patients who lived at least 2 months, the incidence and diversity of second tumors were similar to those in normal persons of the same age and d...

journal_title：Annals of internal medicine

authors： Stegman R,Alexanian R

更新日期：1979-05-01 00:00:00

abstract：:The diagnosis of gout depends on showing urate crystals in synovial effusions or, with less certainty, recognizing a characteristic clinical presentation. The management of gout has four phases: control of inflammation, diagnostic evaluation, education of the patient, and treatment for the hyperuricemia. Sound logical...

journal_title：Annals of internal medicine

authors： Simkin PA

更新日期：1979-05-01 00:00:00

abstract：:Daily change of intravenous (i.v.) infusion administration sets has been recommended by the Center for Disease Control since 1973 to reduce the risk of infusion bacteremia. To evaluate this recommendation, we undertook a prospective, randomized, controlled trial that compared the rates of i.v.-associated bacteremia, i...

journal_title：Annals of internal medicine

authors： Buxton AE,Highsmith AK,Garner JS,West CM,Stamm WE,Dixon RE,McGowan JE Jr

更新日期：1979-05-01 00:00:00

abstract：:Sera of 24 patients with an unexplained pneumonia were tested for the presence of antibodies against the Legionnaires' disease bacterium. Fifteen patients had positive serology. The series comprised 12 male and three female patients ranging in age from 17 to 66 years (mean, 51.1 years). All of the patients had a high ...

journal_title：Annals of internal medicine

authors： Meenhorst PL,van der Meer JW,Borst J

更新日期：1979-04-01 00:00:00

abstract：:Thirty-nine cases of Legionnaires' disease in a 16-month period were identified in visitors to and residents of Bloomington, Indiana. Thirty-five patients had spent at least one night at the Indiana Memorial Union in the 2 weeks before becoming ill. Five of 32 sporadic cases nationwide between 1 January and 31 March 1...

journal_title：Annals of internal medicine

authors： Politi BD,Fraser DW,Mallison GF,Mohatt JV,Morris GK,Patton CM,Feeley JC,Telle RD,Bennett JV

更新日期：1979-04-01 00:00:00

abstract：:We isolated a high molecular weight antigen of the Legionnaires' disease (LD) bacterium by column chromatography. The antigen was composed of 35% carbohydrate, 2.6% protein, 1.8% phospholipid, and 1% 2-keto-3-deoxyoctonate and was important in the host's antibody response because it inhibited the indirect immunofluore...

journal_title：Annals of internal medicine

authors： Johnson W,Elliott JA,Helms CM,Renner ED

更新日期：1979-04-01 00:00:00

abstract：:Tissues from guinea pigs inoculated intraperitoneally with the Legionnaires' disease (LD) bacterium were studied with light, immunofluorescent, and electron microscopy. The principal gross lesion was diffuse peritonitis of varying severity. Microscopically, the peritonitis of covered by a mixed inflammatory infiltrate...

journal_title：Annals of internal medicine

authors： Chandler FW,McDade JE,Hicklin MD,Blackmon JA,Thomason BM,Ewing EP Jr

更新日期：1979-04-01 00:00:00

abstract：:The clinical implications of newly acquired left bundle-branch block (LBBB) were examined prospectively in the Framingham Study population. During 18 years of observation 55 people developed LBBB. The mean age at the onset of LBBB was 62; LBBB occurred largely in people with antecedent hypertension, cardiac enlargemen...

journal_title：Annals of internal medicine

authors： Schneider JF,Thomas HE Jr,Kreger BE,McNamara PM,Kannel WB

更新日期：1979-03-01 00:00:00

abstract：:We ascertained the incidence of hypercalcemia in 79 consecutive patients with active pulmonary tuberculosis and a control group of 79 patients with chronic obstructive pulmonary disease. Twenty-two patients developed hypercalcemia (serum calcium greater than 10.5 mg/dl) within 4 to 16 weeks after initiation of chemoth...

journal_title：Annals of internal medicine

authors： Abbasi AA,Chemplavil JK,Farah S,Muller BF,Arnstein AR

更新日期：1979-03-01 00:00:00

abstract：:To describe more explicitly the components of competence required of the internist, The American Board of Internal Medicine has analyzed the medical encounter and defined the major variables involved: the abilities required of the internist, the tasks that must be performed to solve a medical problem, the medical illn...

journal_title：Annals of internal medicine

authors：

更新日期：1979-03-01 00:00:00

abstract：:Advances through basic research have elucidated the disturbances of neurotransmitter function in Parkinson's Dopamine has replaced acetylcholine and norepinephrine as the most studied neurotransmitter, with both conceptual and practical developments, exemplified by the hypothesis of cyclic adenosine monophosphate as a...

journal_title：Annals of internal medicine

authors： Calne DB,Kebabian J,Silbergeld E,Evarts E

更新日期：1979-02-01 00:00:00

abstract：:Computerized axial tomography permits accurate cross-sectional radiographic visualization of visceral organs. Thus, "radiographic area" of an organ slice can be calculated and converted to actual area from a standard grid printed on the roentgenogram. Because the width between slices is known, the volume of an organ s...

journal_title：Annals of internal medicine

authors： Heymsfield SB,Fulenwider T,Nordlinger B,Barlow R,Sones P,Kutner M

更新日期：1979-02-01 00:00:00

abstract：:After marketing, drugs should be evaluated for safety and for efficacy. Present national systems are inadequate for both tasks. Safety can be evaluated by means of nonexperimental research, whereas evaluation of efficacy in a variety of settings representing normal medical practice generally requires experiments, rand...

journal_title：Annals of internal medicine

authors： Slone D,Shapiro S,Miettinen OS,Finkle WD,Stolley PD

更新日期：1979-02-01 00:00:00

abstract：:A lack of national health goals has allowed physician manpower policy to be dominated by an expansionist philosophy. Scarce resources have been channeled into the production of specialist physicians trained to provide complex and expensive care for uncommon diseases, using other scare and expensive resources and addin...

journal_title：Annals of internal medicine

authors： Bloom BS,Peterson OL

更新日期：1979-02-01 00:00:00

abstract：:The diagnostic and therapeutic value of the angiotensin converting enzyme inhibitor teprotide (SQ 20881) was assessed in 18 patients with hypertensive emergencies. Mean blood pressure fell 31 +/- 18 mm Hg in the 10 subjects who responded to 1 mg/kg body weight administered intravenously, whereas it fell 5 +/- 3 mm Hg ...

journal_title：Annals of internal medicine

authors： Tifft CP,Gavras H,Kershaw GR,Gavras I,Brunner HR,Liang CS,Chobanian AV

更新日期：1979-01-01 00:00:00

abstract：:The question of whether initial treatment is necessary in relatively asymptomatic patients with stage III and IV non-Hodgkin's lymphomas of favorable histologic types was studied by retrospective analysis. Two groups of patients were studied: [1] 44 nonprotocol patients, followed since 1963, in whom initial treatment ...

journal_title：Annals of internal medicine

authors： Portlock CS,Rosenberg SA

更新日期：1979-01-01 00:00:00

abstract：:Prospective data at Framingham and elsewhere have shown conclusively that risk of coronary heart disease in persons younger than age 50 is strikingly related to the serum total cholesterol level. Within so-called normal limits risk has been found to mount over a five-fold range. The impact has been found to be augment...

journal_title：Annals of internal medicine

authors： Kannel WB,Castelli WP,Gordon T

更新日期：1979-01-01 00:00:00

abstract：:Recently acquired knowledge about vitamin D metabolism has improved our understanding in different varieties of osteomalacia. Many new causes of osteomalacia continue to be found. Radiologic and biochemical changes are not always characteristic and may occasionally be misleading. Bone biopsy after a double tetracyclin...

journal_title：Annals of internal medicine

authors： Frame B,Parfitt AM

更新日期：1978-12-01 00:00:00

abstract：:Aspects of phosphate biochemistry pertinent to therapy, the distribution of phosphorus in body compartments, therapeutic phosphorus preparations, prevention of hypophosphatemia, therapeutic guidelines, and side-effects of phosphorus therapy are reviewed. Severe hypophosphatemia (less than 0.32 mmol/litre or less than ...

journal_title：Annals of internal medicine

authors： Lentz RD,Brown DM,Kjellstrand CM

更新日期：1978-12-01 00:00:00

abstract：:The expression of ischemic heart disease was studied in a large kindred with familial hypercholesterolemia. Tendon xanthomas, multiple generation transmission, and the appearance of bimodality in the distributions of total and low-density lipoprotein cholesterol were found. The segregation ratio was 0.9 in females and...

journal_title：Annals of internal medicine

authors： Streja D,Steiner G,Kwiterovich PO Jr

更新日期：1978-12-01 00:00:00